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Besides, caffeic acid and chlorogenic acid (caffeoylquinic acids) are two other classical phenolic acids widely found in natural plants, both of which are the most vital active substances in coffee [168]

Hall et al., 2020), especially in patients with hypertension and coexisting conditions where blood pressure control is the primary, sometimes the only goal (Ramsay et al., 1994

257,258,259,260 Microglia-derived TNF-, for example inhibits viral replication in astrocytes, 259 while microglial IL-6 reduces neuronal death

That is a crucial distinction: cosmetic ingredients are regulated primarily for safety in their intended cosmetic use, not for demonstrated therapeutic efficacy