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When initiating semaglutide in patients already taking levothyroxine, clinicians may consider checking TSH levels 6-8 weeks after starting treatment, particularly for patients using oral semaglutide (Rybelsus) due to its documented effect on thyroxine exposure

While these are generally mild to moderate, it is important to monitor any new or worsening symptoms and communicate them to your healthcare provider promptly

Popik, P., Kos, T., Zhang, Y

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Patients suffering from medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) or with a family history of these conditions, should not take it