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A 28-week study showed that the 15mg dose produced an average body weight loss of 7.38 percent compared to 2.28 percent with placebo

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The importance of W33 in small-molecule activation of GLP-1R was curious since it is located on the extracellular domain (ECD), distal from the transmembrane domains and connecting loops directly involved in peptide-induced GPCR activation ( 20, 32 )