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Weight loss may be negligible or even slightly positive due to the washout period weight regain stabilizing

9.5 Other GSH-responsive therapeutic strategies Modalities GSH-activated nanomedicines were also developed for other therapies, including photothermal therapy

This is also supported by the fact that besides KIT and PTEN , mutations in PI3K and AKT homologous of PI3K-AKT-mTOR are scarce (4.8% PIK3CA , 3.8% PIK3CG , and 4.8% AKT3 ) ( 105)

Based on these findings, inhibiting GSK3 could be a novel therapeutic strategy for the treatment of patients with T2DM, not only by enhancing insulin sensitivity, but also by improving insulin secretion

ClueGO: A Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

PMID: 26500843