Treatment is usually limited to up to 2 years
Vomiting bile or repeated yellow-green vomiting deserves caution
While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition
These medications carry a boxed warning about thyroid C-cell tumors (contraindicated with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings about potential risks including pancreatitis, gallbladder disease, acute kidney injury with dehydration, and worsening diabetic retinopathy with rapid glucose reduction (particularly with semaglutide)
Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5 24 million UK adults
Overall, our data suggest that females show reduced glucose-lowering benefit from GLP1-M treatment Table 4)