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Material and methods Cell culture HeLa (ATCC Number: CCL-2) and SHSY-5Y (ATCC Number: CRL-2266) cells, STR profiled and free from any contamination, were sourced from National Center for Cell Science repository

ER is a center for the biosynthesis of extracellular and organelle proteins

Turner Publishing Co, 2016

However, it must be emphasized that ferroptosis lacks morphological distinctions from other forms of necrotic cell death [16]

doi: 10.1016/bs.afnr.2017.11.001 37 TylickiASiemieniukM

Additionally, ROS also serve as signaling molecules in cancer, which affect receptor and oncogene activity, as well as alter several signaling pathways or oxidizing enzymes, facilitating tumorigenesis, angiogenesis, cellular proliferation, invasiveness, and metastasis (14)