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[5] [6] In some countries, particularly in Eastern Europe, meldonium is used to treat problems with brain circulation and has been reported to elevate mood and improve motor symptoms, dizziness, and nausea

However, the itaconate shunt hypothesis, developed by Phair, Armstrong, and Davis, proposes the itaconate pathway does not turn off in individuals with ME/CFS [74,75,76,77]

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Using Kratom can result in seizures, liver failure, psychosis, and overdoses especially when its mixed with alcohol or other drugs

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Acylcarnitines function as lipid carriers, supporting lipid metabolism and reflecting -oxidation activity in mitochondria 25,26