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Since cell membranes are negatively charged, peptide drugs can efficiently penetrate membranes when their overall charge is neutral or positive 42

Most are dose-related, more common during escalation of dose, and often improve over weeks as the body adapts

Notably, rituximab ameliorates dyslipidemia in refractory SLE cases and attenuates myocardial infarction risk through pleiotropic immunometabolic mechanisms (157)

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Relationship between energy requirements for Na+ reabsorption and other renal functions