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In addition, manganese oxide nanomaterials (MONs), including MnO 2 , Mn 2 O 3 , and Mn 3 O 4 , possess a similar GSH elimination property to Cu-based nanomaterials, and react with GSH along with the decomposition of MnO x into Mn 2+ for initiation of the Fenton-like reaction (Qian et al., 2020)

Adverse Reactions/Side Effects Mild transient diarrhea, itching, transitory exanthema, feeling of swelling of entire body, and anaphylaxis

Nat Rev Drug Discov (2021) 20:689709

By targeting key molecular pathways such as Wnt/-catenin, SMAD, PI3K/AKT, and MAPK/ERK, these therapies can modulate gene expression, cell signaling, and protein synthesis to optimize healing outcomes

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Structural insights into the HNF4 biology