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p53 activation can suppress the mitochondrial tricarboxylic acid cycle and oxidative phosphorylation through inhibition of malic enzymes 1/2 or by inducing a PUMA-dependent metabolic switch (Jiang et al, 2013

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Because GLP-1 medications lead to weight loss that includes fat and muscle, the skin will lose some of its collagen content, explains board-certified dermatologist Raja Sivamani, MD, MS, AP

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F( 3, 28 ) = 0.89

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