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Targeting GLP-1 receptor trafficking to improve agonist efficacy

FOXO4-DRI is a senolytic peptide a D-retro-inverso peptide engineered to selectively eliminate senescent "zombie" cells that accumulate with age and secrete inflammatory factors (the senescence-associated secretory phenotype, or SASP)

Supports investigation of tissue structural rejuvenation: Accumulated senescent cells can impair tissue architecture by altering cell-to-cell communication and extracellular matrix composition

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Mowed yard and while my eyes were itchy from the grass my nose throat and chest stayed clear

10.1016/j.cell.2018.07.048 Cell 41 De VadderF.GrassetE.Manneras HolmL.KarsentyG.MacphersonA