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These findings underscore that GSH regulates ferroptosis not only through peroxide detoxification but also by coordinating iron trafficking and Fe-S cluster integrity, thereby coupling redox defense to core metabolic fitness

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Multiple studies have shown that expressions and activities of cytochrome P450 enzymes were also positively regulated by some nuclear receptors and transcription factors, including pregnane X receptor (PXR), constitutive androstane receptor (CAR), and retinoid X receptor (RXR) [124], [133], [38],]

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