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Starting too high causes : Severe nausea and vomiting Extreme fatigue Intolerable side effects Protocol abandonment Gradual titration : Minimizes side effects Allows adaptation Improves tolerance Maintains adherence Standard schedule : Start 2.5mg weekly, increase every 4 weeks until reaching maintenance dose
doi: 10.3892/mmr.2014.2555 78 ZhouT.ZhangM.ZhaoL.LiA.QinX
These include: Abnormal behavior Delirium Self-injury Exacerbation of irregular heartbeat (arrhythmia) Anaphylaxis (a severe allergic reaction that includes trouble breathing and a dangerous drop in blood pressure) Severe allergic skin reactions, including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis Tamiflu and neuropsychiatric disorders Tamiflu treatment has been associated with neurological and psychiatric adverse events when used to treat or prevent flu infection, particularly in children
However, because GLP-1 treatments typically begin at a low titration dose to allow the body to adjust and minimize side effects, the appetite suppression may feel mild during the first week
Indeed, the experience of several randomized control trials has been included in the most recent guidelines ( In patients with T2DM, the treatment with SGLT2-i has been associated with a reduction in hospitalization for heart failure and cardiovascular deaths, regardless of pre-existing cardiovascular disease ( Several studies ( This heterogeneity in CV benefits across the trials, also among studies in which drugs of the same class have been used, could be explained by different study designs (i.e
