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A clinical trial of 71 women with mild to advanced photoaging found that daily application of a GHK-Cu facial cream for three months significantly increased skin density and thickness, reduced sagging, and improved the appearance of fine lines and wrinkles compared to placebo
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The protein expression levels of tight junction associated protein-1 (ZO-1), Occludin, inflammatory factors interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, SIRT1, STAT3, p-STAT3, and retinoic acid receptor-related orphan receptor gamma t (RORt) were detected by Western blot
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