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found that TMAO promoted the release of pro-inflammatory cytokines such as IL-1 and TNF- to stimulate the cardiac autonomic nervous system (CANS) and worsen ischemia-induced VA (127)

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Tri-methylamine N-Oxide Trimethylamine N-Oxide is an osmolyte and a metabolite produced in the gut microbiome and is generated from dietary choline, betaine, and L-carnitine 125, 126 crucial for stabilizing protein structures in the presence of urea 126

That is what most media reports missedeven though its the very first sentence of the paper

Coffee has more good benefits than bad side-effects, as long as you stay mindful of avoiding excessive caffeine intake, especially if you suffer from anxiety or high blood pressure

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