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Alpha-synuclein nitration and its implications in Parkinsons disease

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Modulation of the BBB and/or targeted delivery strategies, either taking advantage of this modulation or using the physiological transport pathways to deliver therapeutic compounds into specific parts of the brain, are under extensive study in a pre-clinical setting

In these tumors, the oncogenic effects of ILK may involve regulation of JNK1 phosphorylation, as suggested by Durbin et al., and/or ILK-induced activation of -NAC