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Sean Kelishadi, MD FACS

Although the precise molecular mechanisms of the NLRP3 inflammasome activation remain to be fully elucidated, reactive oxygen species (ROS) are widely regarded as essential for NLRP3 inflammasome activation (111)

The FDA then has to run formal notice-and-comment rulemaking to change a list, a process that can take more than a year, and as of this update nothing has been reclassified