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Within the NHS, NICE guidance typically recommends treatment with Wegovy through specialist weight management services for up to 2 years

15 Nevertheless, no guidelines specifically address the perioperative management of long-acting GLP-1 RAs

Several recently determined non-peptidic ligand-bound GLP-1R structures 13,14,16 have uncovered previously unknown binding pockets that may have implications in their pharmacological profiles such as biased signaling and allosteric agonism (Supplementary Fig