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Fluctuations in ROS levels can influence the function of protein kinases, phosphatases, and various enzymatic proteins, thereby affecting critical processes such as cellular metabolism, gene regulation, and proliferation [25]

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One critical enzyme induced by Nrf2 is NAD(P)H quinone oxidoreductase-1 (NQO1), which detoxifies protein-bound quinone and maintains alpha-tocopherol and coenzyme Q10 in their reduced (antioxidant) states

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Symptoms include right upper quadrant pain, particularly after fatty meals, nausea, and sometimes jaundice

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