Yes, lifestyle habits such as nutrition and physical activity are often discussed as part of a physician-guided weight loss program
For example, the LEADER trial showed that liraglutide reduced MACEs risk by 13%, while the SUSTAIN-6 trial indicated a 26% reduction with semaglutide
Chanas SA, Jiang Q, McMahon M, et al
In this randomized trial of more than 9300 subjects with T2DM and high cardiovascular risk, liraglutide was seen to decrease the incidence of the composite cardiovascular primary endpoint (occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) compared with placebo (13.0 and 14.9% in the liraglutide and placebo group, respectively
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Higher doses produced larger shares of participants achieving at least 15% weight loss, and more reaching 20% or greater