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Half of the studies reported a reduction in the risk of the composite outcome, similar to the add-on therapy or simultaneous use of the medications

Subsequent trials, including SUSTAIN-6, Harmony Outcomes, and AMPLITUDE-O, reported similar MACE reductions but without a mortality benefit [15,16,17]

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Many providers recommend waiting until nausea or diarrhea improve and then restarting at a lower dose with gradual increases based on tolerance

Most patients notice subtle appetite reduction by day two or three, with more pronounced fullness and reduced cravings by days four through seven