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COMPETING INTERESTS JST reports receiving an investigator-initiated grant, on behalf of the University of Pennsylvania, from Novo Nordisk and receiving consulting fees from Currax Pharmaceuticals, LLC

Vitamin B12 is used to treat pernicious anemia and vitamin B12 deficiency, as well as to determine vitamin B12 absorption in the Schilling test

Whenever the amount of ROS produced by cells increases, the cellular defense mechanism against oxidative stress is activated to clear the cells of ROS [120]

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Fiber is a tool

At a molecular level, glucose transporter 1 (GLUT1), the main glucose transporter across BBB, is densely expressed on the abluminal membrane of the BECs (Winkler et al., 2015)