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This delicate balance is an interplay between ROS production and the up-regulation of the AOX pathways CAT and GSH which opposes the apoptotic process (124)

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Chronic disruption and uncoupling of these interfaces are increasingly recognized as a hallmark of metabolic disorders, including obesity, type 2 diabetes (T2DM), and metabolic dysfunction-associated steatohepatitis (MASH) (Rieusset, 2018)