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Evidence points to the 2-hydroxyestrone metabolite as perhaps the safest estrogen metabolite, so it earns the label of good estrogen, although it is not without potential problems

Women's Health (London) (2016) 5

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Of significance to appetite control, this effect is enhanced with co-administration of leptin

In the group of roughly 600 patients who were taking Ozempic, there were four cases of gastroparesis or stomach paralysis, two cases of pancreatitis, no bowel obstructions, and five who developed biliary disease