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It usually increases rapidly in size to several centimetres and is characterised by acanthosis and spongiosis of the affected epithelium with dendritic melanocytes dispersed throughout the thickness of the epithelium, with a mild inflammatory cell infiltrate in the superficial lamina propria [11, 13, 34]

In addition to energy production, vitamin B12 is essential for maintaining the health of the nervous system and red blood cell production

l-Lactate was quantified in the filtrate with an assay kit (#MAK064, Sigma-Aldrich) via colorimetric (570 nm) measurements in a Varioskan Flash Reader using the manufacturer's protocol

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Active RA was diagnosed in 58% of the patients

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