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Clinical Evidence : Meta-analyses show a statistically significant but very small weight loss of approximately 2.4 lbs compared to placebo, below the threshold for clinical significance

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doi:10.1056/NEJMoa1410489 Nicholls SJ, Puri R, Anderson T, et al

After seeing its positive effects in this population and its common assistance in weight loss, Semaglutide received official approval in 2021 to be used in patients who might be struggling to lose weight