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Thats because, while HA occurs naturally in the skin, we produce less as we age, when we need it the most

Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )

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Innate immunology in COVID-19a living review

Lima et al., 2010)