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Abnormalities of glucose metabolism and metabolic acidosis may occur

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Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase

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The promotion of skeletal muscle triglyceride synthesis in response to insulin presents a paradox given that in patients with type 2 diabetes and insulin resistance there is marked elevation in intramuscular triglyceride levels

Based on the characteristics of the patients intestinal microbiome, personalized microbiome intervention plans should be formulated