Results vary based on medication, adherence, and individual metabolism
Study designs to investigate causality rigorously Prospective new-user cohort with active comparator + Recruit new semaglutide users and matched new users of a comparator second-line diabetes therapy with lower genital infection confounding (e.g., DPP4 inhibitor), stratified by menopausal status and baseline GSM
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However, the study design did not allow for the assessment of the effects of semaglutide on bone metabolism, independent of weight loss, as the control group did not experience comparable weight reduction
Serum concentrations of vitamin B12 during treatment were in the high range of normal or above normal
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