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Blake GM, Fogelman I

GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet cells, promotion of islet cell proliferation and minimal side effects

Legal, Regulatory, and Economic Unrest in the GLP-1 Space GLP-1s like tirzepatide (Zepbound, Mounjaro) have faced tightening FDA regulations

Thus, drugs that target GIP, GLP-1, or GLP-2 receptor signalling pathways could be employed for treating bone diseases

But they underscore the importance of careful medical oversight

doi: 10.1056/NEJMoa1509225 251 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al