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Inflammatory and apoptotic markers (TNF-, NF-B, caspase-3, IL-6, Nrf2, BCL-2, and Bax) were also assessed, supported by histopathological evaluation

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In this regard, it has been shown that SSTR5 exerts antiproliferative and antisecretory effects in somatotroph by coupling with the inhibitory G protein G oA , independently of cAMP reduction, suggesting a dissociation between these pathways (11, 42)

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