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Protease signalling: the cutting edge

Inhibitory effect of unconjugated bile acids on the enterohepatic circulation of methotrexate

A study at Penn Medicine, funded by Novo Nordisk, found that participants taking semaglutide lost an average of 16% of their starting weight and more than one-third lost 20% or more of their baseline weight during the 68-week study

13 : 439445 Kobayashi S, Zimmermann H, Millhorn DE

These medications have clear data on long-term effects, including sustained weight loss, improved metabolic markers, and tolerability patterns

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