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Over time, perifollicular fibrosis essentially chokes off follicle function

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These drugs have proven highly effective, with patients often experiencing significant weight loss and improved metabolic health

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They work through several important mechanisms: They increase insulin release from the pancreas when blood glucose is high They reduce excess glucose release from the liver They slow stomach emptying, helping prevent sharp glucose spikes after meals They increase feelings of fullness, often reducing appetite Because these effects depend on blood glucose levels, GLP-1 medications on their own carry a very low risk of causing low blood sugar (hypoglycaemia)