It facilitates the transport of fatty acids into mitochondria for subsequent oxidation and energy production
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Collectively, this raises the notion that the observed differences here are perhaps related to long-term selenium intake, a micronutrient that has been speculated to play a role in konzo pathogenesis, due to its essential requirement for maintaining antioxidant machinery 18
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For senescence-related genes, we curated Senescence, Induced Senescence, and Inhibited Senescence-associated genes were compiled from the Database of Cell Senescence Genes ( All remaining pathways used in this study were derived from previously published custom metabolic and immune gene sets ( Figure preparation Summary schematics and conceptual illustrations were created using BioRender (BioRender.com)