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Subsequent studies have proved that activation of Nrf2 and inhibition of Keap1 lead to SLC7A11 upregulation, thereby promoting resistance to ferroptosis (Fan et al., 2017).The expression of SLC7A11 can also be inhibited by transcription factors such as Tumor protein p53 (p53) and Activating transcription factor 3 (ATF3)

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While the rigorous study confirmed that high-dose CoQ10 was entirely safe and well-tolerated, it did not demonstrate a statistically significant reduction in overall symptom severity compared to the placebo over the 6-week intervention periods

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