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For instance, administering IGF-1R mAbs in cancer trials was reported to result in increased adverse events in younger populations 34 , including insulin resistance, possibly due in part to disruption of the somatotropic axis and associated deleterious effects of excess GH 41,42

doi: 10.1089/10799900152434402

A total of 46.4% of patients with locally advanced BCC and 30.8% of patients with metastatic BCC demonstrated some response to treatment

92 It has been difficult to apply these findings to humans as resistin secretion is different between these two species

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