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References Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P

Safety: What Are the Risks

NICE guidelines for weight management emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery

Titration Start tirzepatide alone for 8 weeks, then add cagrilintide at 0.25 mg/week

& French, L

This is fundamentally different from the injection site profile of tirzepatide or semaglutide , which generally produce minimal injection site reactions