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Authors contributions Designed and conducted the study, performed data acquisition and analysis, and wrote the manuscript: Zhang W, Xue J Collected and managed data: Wang J, Ni D, Zhou W Performed data management: Wang B, Shi J Conceived and designed the study, conducted it, interpreted the data, and revised the manuscript: Wang A All the authors have read and approved the final version of this manuscript

GLP-1 exerts its actions by binding to a G-protein coupled receptor (GLP-1R) expressed on the surface of many cells including -cells, which, upon stimulation, leads to rapid activation of adenylyl cyclase thus increasing cAMP levels 7

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The haptocorrinB12 complex then moves to the stomach, pylorus, and duodenum