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Additionally, it enhanced NO production and improved endothelium-dependent vasorelaxation in isolated rat aortas, suggesting its potential to mitigate dietary cholesterols atherogenic effects (Li et al., 2009)

Beyond their original design for diabetes and the notable side effect of losing significant amounts of weight, clinical trials have shown that GLP-1s reduce the risk of heart attacks, strokes, kidney disease progression, heart failure, and even COVID-19 mortality

Current clinical evidence suggests GLP-1 medications should be discontinued before conception and throughout pregnancy, though individual circumstances vary based on metabolic health and medical history

The evidence for microdosing as a maintenance strategy is still emerging

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