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Significantly, as shown in Figure 6 in their Extended Data ( only to the inactive M pro C145A mutant, and concluded it was a likely M pro substrate, because they were able to identify a putative M pro cleavage site in the TRMT1 protein sequence (PRLQ/ANFT), where the slash (/) represents the cleavage site

Twenty-three people switched to dosing around every two weeks (at least 10 days), while 7 switched to longer-spaced doses, including one who opted to wait every five to six doses