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The incretin effect is reduced in people with T2DM, mainly because GIP has less of an impact [85]

TREASURE-CKD, A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes (NCT05536804)

Xia, J., Psychogios, N., Young, N

Appetite suppression : Some users report reduced appetite, which can be advantageous for weight management

Climate control seemed lacking

In a November 2024 article, researchers testing Cardalis (benazepril and spironolactone) on the RAAS in healthy dogs intentionally activated their RAAS by feeding them the low-sodium diet of Hill's Prescription h/d Heart Care