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Importantly, hemodynamic effects - modest reductions in heart rate (+2-4 bpm) and blood pressure decreases - are generally well tolerated and beneficial in this population

During the phase 3 trial of tirzepatide, 6.6% of patients discontinued the medication due to side effects [114]

These medicines help lower blood sugar, reduce appetite, and often support weight loss

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Lilly's Phase 3 TRIUMPH program targets a mid-2025 NDA submission, placing FDA approval most realistically in mid-to-late 2026 under a standard review

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