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A: Both approaches have proponents

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Xanthine Oxidase Xanthine oxidase (XO) is a form of xanthine oxidoreductase, a type of enzyme that generates ROS

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At the cellular level, metabolic dysfunction and DM promote oxidative stress, loss of stem cell function, inflammation, glymphatic pathway dysfunction, absence of mitochondrial homeostasis, endothelial cell impairment, neuronal cell injury, myelin degradation, and changes in neurotransmitter release [69]