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The systolic reduction from semaglutide contributed to a 20% reduction in major cardiovascular events

To stay ahead of this shifting environment, pharma companies should consider the following imperatives: Massive patient drop-off undermines obesity GLP-1 uptake: Despite strong demand, only 10% of obesity patients persist with therapy after one year

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Your solution is simply more dilute than intended

Kang, D.-H., Kwon, S.-H., Sim, W.-Y., & Lew, B.-L

GI effects dominate: nausea (35-60%), diarrhea (20-40%), vomiting (~20%), and constipation (20-30%) at higher doses