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R747W is a mutant phenotype with loss-of-function of the gene encoding iPLA2, which reduces the hydrolytic activity of 15-HpETE-PE, and increases the content of 15-HpETE-PE in cells, and increases the sensitivity to ferroptosis compared with the wild type

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Although repeated dosing will shift the liver size and cell content to a higher metabolic steady state, continued dosing does not stimulate further increase in liver size (Crampton et al

RETA improved glucose tolerance compared to baseline tolerance tests at the start of the study, as well as compared to Veh at study midpoint (Supplementary Figs

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Freeman et al., 2006)