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Importantly, we found that phosphorylation of serine 727 residue of STAT3, p-STAT3-S727, increased in hyperaminoacidemia-treated cells, further elevating Vgf transcription in an mTOR-dependent manner

[PMC free article] [PubMed] [Google Scholar] 152.Nauseef WM

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Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

However, the limited follow-up duration of 6 months raised concerns about potential reverse causality, as undetected suicidal ideation and medical conditions might have influenced the choice of particular anti-obesity or anti-diabetic drugs

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