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Furthermore, at the intestinal level, TCDCA-mediated activation of FXR leads to impaired nutrient-sensing mechanisms that regulate glucose homeostasis 273

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For instance, research has shown that low levels of serum IGF-1 are associated with impaired glucose tolerance and an increased risk of type 2 diabetes

For "acute" intake, it is suggested to consume LC 30 to 120 days before exposure to load (Bartels et al

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In industrial light water production, however, distillation is used as it is more efficient