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Furthermore, increased apoptosis of LECs has been implicated in the development of diabetic cataracts in both human and animal models 66,67

Additionally, extracellular matrix-modifying enzymes like metalloproteinases contribute to epithelial-mesenchymal transition (EMT), facilitating cancer development 34

Again, given the potential dependence of cerebellar function on neuronal synchrony, it could be that DBS ultimately serves to normalize activity within an existing internal framework that packages cerebellar circuits into distinct functional modules

Fatigue and a feeling that something is OFF One of the earliest but most least discussed symptoms is fatigue Long before the joints become swollen, many people describe feeling unusually exhausted, drained, or foggy

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You likely have more sitting-around time than youre used to