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Its active form, 1,25-dihydroxyvitamin D, crosses the bloodbrain barrier and binds to vitamin D receptors (VDRs) widely expressed in areas critical for cognition, such as the hippocampus, cortex, and substantia nigra (58, 59)

There is concern that the large accumulation of ACs may be toxic in long-chain fatty acid oxidation disorders (Watanabe et al., 2018)

People with type 2 diabetes , high blood pressure, high cholesterol, obstructive sleep apnea, smoking, and certain optic nerve anatomical features are known to have a higher risk of developing the condition (2 Trusted Source Ischemic Optic Neuropathies Go to source)

Interplay between inflammation and thrombosis in cardiovascular pathology