A subgroup meta-analysis was conducted based on the type of GLP-1 RA used, separately for three treatment durations: 3 months, 6 months, and 12 months
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If side effects were the issue, other GLP-1 receptor agonists with different formulations (such as once-weekly injectable semaglutide, dulaglutide, or liraglutide) may be better tolerated, though gastrointestinal effects are common across this drug class
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Consistent with this, our in vitro results showed that semaglutide treatments markedly increased PA-stimulated cell viability, and increased expression of METTL3/14, PDX-1
Subsequently, in August 2025, semaglutide, a representative drug of GLP-1RAs, also obtained FDA approval, targeting the same indications as Resmetirom (8)